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| Selective estrogen receptor modulator ： ウィキペディア英語版 |
Selective estrogen-receptor modulator
Selective estrogen receptor modulators (SERMs) are a class of compounds that act on the estrogen receptor. A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues, thereby granting the possibility to selectively inhibit or stimulate estrogen-like action in various tissues. Phytoserms are SERMs from a botanical source.
==Members and uses==
SERMs are used dependent on their pattern of action in various tissues:
Other members include afimoxifene, arzoxifene, and bazedoxifene.
Some SERMs may be good replacements for hormone replacement therapy (HRT), which had been commonly used to treat menopause symptoms until the publication of wide scale studies showing that HRT slightly increases the risk of breast cancer and thrombosis. Some of the above agents still have significant side-effects that contraindicate widespread use.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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